Cyrille BOTTÉ |
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Information |
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Institute of Advanced Biosciences | ||
Apicolipid: Membrane biogenesis, lipid synthesis and nutrient acquisition of Apicomplexan parasites and their human host cells | ||
Grenoble | ||
0000-0002-2245-536X | ||
This email address is being protected from spambots. You need JavaScript enabled to view it. | ||
https://iab.univ-grenoble-alpes.fr/ | ||
@ApicoLipid | ||
Scientific interests and projects |
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The research team I currently lead (https://NotAllowedScript6606702dce5aatwitter.com/ApicoLipid @ApicoLipid) as CNRS Research Director focuses on understanding how Apicomplexan parasites acquire lipids and nutrient essential for their propagation and survival within their host cells. Apicomplexa are unicellular eukaryotes and pathogenic agents responsible for major human diseases such as Toxoplasmosis, major chronic disease affecting ~1/3 of the world population and a lethal threat to immunocompromised patients, and (ii) malaria affecting 250 millions people/year, killing ~1/2million/year, mainly children. The renewal of our therapeutic arsenal needed for the eradication of these diseases depends on deciphering metabolic pathways that sustain parasite survival within the host and its environment. Current evidences all point at lipid synthesis and membrane biogenesis as crucial pathways for parasite intracellular development. Major biological questions remain and focus our current attention (i) how are lipids acquired, remodelled and trafficked from the host cell to the parasite and between parasite intracellular compartments? (ii) what is the input of scavenged vs de novo synthesised lipids? (iii) what are the mechanisms of lipid fluxing and trafficking from these two pathways? (iv) how does parasites sense and regulate these pathways to adapt to physiological changes of host nutritional and environmental conditions? (v) what are the parasite lipid signals required for intracellular development? Our laboratory have set up major facilities and equipements that includes a P3* cell culture facility (MESRI-HCB), and a fully independent lipidomic-fluxomic platform encompassed within our P3* (http://gemeli-uga.fr/GEMELI.html), both parts of the core facilities of our Institution at the Université Grenoble Alpes. Our robust expertise and facilities thus allows us to conduct large metabolomics and lipidomics analyses beyond our central scope, on infectious diseases and other models, to determine metabolic signatures or monitoring metabolite fluxes. We currently lead major collaborative projects with national and international partners (LIA University Melbourne/WEHI, CEFIPRA ICGEB New Dehli…). |
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Top 5 publications of the last 5 years |
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1. Amiar S, Katris NJ, Berry L, Dass S, Shears MJ, Brunet C, Touquet B, McFadden GI, Yamaryo-Botté Y*, Botté CY*. (2019) Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodelling, Accepted in Cell Reports, (CELL-REPORTS-D-19-01152) 2. Dubois D, Fernandes S, Amiar S, Dass S, Katris NJ, Botté CY*, Yamaryo-Botté Y*. (2018)(*colast and corresponding) Toxoplasma gondii acetyl-CoA synthetase is involved in fatty acid elongation (of long fatty acid chains) during tachyzoite life stages. J Lipid Res. 59(6):994-1004 3. Shears MJ, MacRae JI, Goodman DG, Mollard VSU, Botté CY *, McFadden GI*. (2017) (*co-last) Characterization of the Plasmodium falciparum and P. berghei glycerol-3-phosphate acyltranferase involved in FASII fatty acid utilization in the malaria parasite apicoplast. Cellular Microbiology 19(1) 4. Amiar S, MacRae JI, Callahan DL, vanDooren GG, Shears MJ, Dubois D, Cesbron-Delauw MF, Maréchal E, McConville MJ, McFadden GI, Yamaryo-Botté Y*, Botté CY *. (2016) The Toxoplasma gondii apicoplast is responsible for bulk phospholipid synthesis mainly via a plantlike glycerol 3-phosphate acyltransferase for lysophosphatidic acid precursor assembly. Plos Pathogens 4;12(8):e1005765 5. Bullen H+, Jia Y+, Yamaryo-Botté Y, Klages J, Carruthers V, Botté CY, Soldati-Favre D. (2016) . Phosphatidic acid-mediated signaling is essential for microneme secretion in Toxoplasma. Cell Host and Microbe 9;19(3):349-60 |
Ana Rita Gomes, a CNRS Research Associate at the Laboratory of Pathogens and Host Immunity in Montpellier, and former Postdoctoral fellow of the LabEx ParaFrap, has been awarded the prestigious CNRS Bronze Medal in 2023. This...
. PhD Opportunity, Tours, France Supervision Thesis Supervisor: Sonia LAMANDE; Co-Supervisor: Julie TOTTEY Project: FUNTIONAL CHARACTERISATION OF CYSTEINE CATHEPSINS IN THE APICOMPLEXAN PARASITE CRYPTOSPORIDIUM...
Senior PostDoc position : computational biologist, Paris, France The ParSig team (https://research.pasteur.fr/en/team/molecular-parasitology-and-signaling) at the Institut Pasteur in Paris seeks for a highly...
Researcher in Livestock Immunology for the Study of Animal Trypanosomoses Through a One Health approach, the Intertryp Joint Research Unit (Cirad-IRD) is developing research on interactions between hosts,...
Happy New Year 2024! To kick off this new scientific year, here is the ParaFrap webinar schedule. Since January 2021, ParaFrap has been organizing a series of webinars. This monthly event, held every 2nd Thursday of the month, aims to strengthen...
PostDoc position : functional analysis of P. falciparum early gametocyte proteins, Allschwil, Switzerland The Malaria Gene Regulation Lab of Till Voss is looking for a highly motivated and talented postdoc to...
The team of Dr. Mohamed-Ali Hakimi, in collaboration with Isabelle Coppens (Johns Hopkins University Bloomberg School of Public Health and Malaria Research Institute, Baltimore, MD, USA), has developed a new (epi)genetic method to produce in vitro...
Success for ParaFrap students at MPM2023 Parafrap students won numerous awards at the MPM 2023, Woods Hole USA, 17-21 September 2023. A warm congratulations to all ! Parul Sharma (2nd year PhD under the...
Predoctoral and Postdoctoral positions - Barcelona, Spain Project Leader: Alfred Cortés, PhD - Barcelona Institute for Global Health Hospital Clínic - Universitat de Barcelona Positions: A predoctoral and two...
PhD Position Perpignan, France Project Leader Ronaldo DE CARVALHO AUGUSTO (CPJ, UPVD), principal supervisor (50%) Jérôme BOISSIER (PU, UPVD), PI (50%) Project: Unveiling the Dark Secrets of Roommate Parasites: A Study...
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