Catherine LAVAZEC |
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Information |
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Institut Cochin, CNRS UMR 8104, Inserm U1016 | ||||||
Biology of Plasmodium transmission | ||||||
Paris | ||||||
0000-0003-1533-7282 | ||||||
This email address is being protected from spambots. You need JavaScript enabled to view it. | ||||||
https://www.institutcochin.fr/la-recherche/3i/equipe-lavazec | ||||||
Scientific interests and projects |
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Our team aims to dissect the interactions between Plasmodium falciparum transmission stages (gametocytes) and the human host. Our work is oriented in 4 main axes: i) Decipher how gametocytes modify the biomechanical properties of their infected host cell ii) Unravel the interactions of gametocytes with the bone marrow microenvironment iii) Address in vivo the mechanisms underlying the sequestration and the circulation of gametocytes in their host We perform in vivo imaging in a humanized mouse model that we have recently set up to decipher the mechanisms underlying sequestration and circulation of gametocytes. This mouse model also allows to test in vivo transmission-blocking drugs. iv) Generate a novel anti-malarial transmission-blocking drug |
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Top 5 publications of last 5 years |
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1. Neveu G, Dupuy F, Ladli M, Barbieri D, Naissant B, Richard C, Martins RM, Lopez Rubio JJ, Bachmann A, Verdier F, Lavazec C. Plasmodium falciparum gametocyte-infected erythrocytes do not adhere to human primary erythroblasts. Scientific Reports 2018 Dec 14;8(1):17886. doi: 10.1038/s41598-018-36148-y 2. Naissant B, Dupuy F, Duffier Y, Lorthiois A, Duez J, Scholz J, Buffet P, Merckx A, Bachmann A, Lavazec C. Plasmodium falciparum STEVOR phosphorylation regulates host erythrocyte deformability enabling malaria parasite transmission. Blood 2016 Jun 16;127(24):e42-53. doi: 10.1182/blood-2016-01-690776 3. Duffier Y, Lorthiois A, Cisteró P, Dupuy F, Jouvion G, Fiette L, Mazier D, Mayor A, Lavazec C#, Moreno-Sabater# A. (# co-last author). A humanized mouse model for sequestration of Plasmodium falciparum sexual stages and in vivo evaluation of gametocytidal drugs. Scientific Reports 2016 Oct 12; 6:35025. doi: 10.1038/srep35025 4. Bargieri DY, Thiberge S, Tay CL, Carey AF, Rantz A, Hischen F, Lorthiois A, Straschil U, Singh P, Singh S, Triglia T, Tsuboi T, Cowman A, Chitnis C, Alano P, Baum J, Pradel G, Lavazec C, Ménard R. Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes. Cell Host & Microbe 2016 Nov 9;20(5):618-630. doi: 10.1016/j.chom.2016.10.015 5. Ramdani G, Naissant B, Thompson E, Breil F, Lorthiois A, Dupuy F, Cummings R, Duffier Y, Corbett Y, Mercereau-Puijalon O, Vernick K, Taramelli D, Baker D, Langsley G, Lavazec C. cAMP-signalling regulates gametocyte-infected erythrocyte deformability required for malaria parasite transmission. PLoS Pathogens 2015 May 7;11(5):e1004815. doi: 10.1371/journal.ppat.1004815 |
The York Biomedical Research Institute (YBRI) are hosting an online live seminar on Friday 24th May 1-2pm BST as part of their biomedical science seminar series. You are all welcome to attend - registration is required via the...
[Communiqué] Congratulations to Arthur Talman, IRD Research Leader in the MIVEGEC laboratory (Montpellier), who has been awarded an Advanced Grant from the European Research Council (ERC) for the project "TROJAN - Molecular mimicry and immune...
Ana Rita Gomes, a CNRS Research Associate at the Laboratory of Pathogens and Host Immunity in Montpellier, and former Postdoctoral fellow of the LabEx ParaFrap, has been awarded the prestigious CNRS Bronze Medal in 2023. This...
. PhD Opportunity, Tours, France Supervision Thesis Supervisor: Sonia LAMANDE; Co-Supervisor: Julie TOTTEY Project: FUNTIONAL CHARACTERISATION OF CYSTEINE CATHEPSINS IN THE APICOMPLEXAN PARASITE CRYPTOSPORIDIUM...
Senior PostDoc position : computational biologist, Paris, France The ParSig team (https://research.pasteur.fr/en/team/molecular-parasitology-and-signaling) at the Institut Pasteur in Paris seeks for a highly...
Researcher in Livestock Immunology for the Study of Animal Trypanosomoses Through a One Health approach, the Intertryp Joint Research Unit (Cirad-IRD) is developing research on interactions between hosts,...
Happy New Year 2024! To kick off this new scientific year, here is the ParaFrap webinar schedule. Since January 2021, ParaFrap has been organizing a series of webinars. This monthly event, held every 2nd Thursday of the month, aims to strengthen...
PostDoc position : functional analysis of P. falciparum early gametocyte proteins, Allschwil, Switzerland The Malaria Gene Regulation Lab of Till Voss is looking for a highly motivated and talented postdoc to...
The team of Dr. Mohamed-Ali Hakimi, in collaboration with Isabelle Coppens (Johns Hopkins University Bloomberg School of Public Health and Malaria Research Institute, Baltimore, MD, USA), has developed a new (epi)genetic method to produce in vitro...
Success for ParaFrap students at MPM2023 Parafrap students won numerous awards at the MPM 2023, Woods Hole USA, 17-21 September 2023. A warm congratulations to all ! Parul Sharma (2nd year PhD under the...
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