Sylviane PIED |
||
Information |
||
Centre d'Infection et d'Immunité de Lille-CIIL-CNRS UMR 8204-INSERM 1019-Université de Lille-Institut Pasteur de Lille | ||
Tropical Biomes and Immunopathophysiology-TBIP | ||
Lille | ||
0000-0003-0642-1423 | ||
This email address is being protected from spambots. You need JavaScript enabled to view it. | ||
https://www.ciil.fr/teams/tropical-biome-immuno-pathophysiology | ||
Scientific interests and projects |
||
TBIP scientific activities focus on (co)transmitted protozoan parasitic diseases in French Guiana Amazonia such as Malaria, Leishmaniasis and Toxoplasmosis. We aim at to elucidating common and divergent immune mechanisms associated with severe disease or protection induced by these protozoan parasite infections and their modulation by environmental parameters on disease outcome in the French Guiana Amazonian ecosystem, a region with abundant biodiversity and a multicultural, multiethnic population, in a “one health” strategy by capitalizing on the strength and multidisciplinary character of the new team consisting of clinicians working on the field, experts in molecular parasitology and epidemiology, and immunologists. The open questions this project will answer through a multidiciplinary integrated workprogram combining conceptual and methodological approaches with experimental and clinical studies are the following: what are the mechanisms of natural protective (or anti-disease) immunity that control the parasite and, limit collateral damage to the host? How are these processes impacted by internal (host) and external (environmental) factors? Does and how the parasite genotype influence the protective response? How do multiple co-transmitted parasites interact to give rise to protection or pathogenesis? The French Amazonian region offers the possibility to study these different parameters in an integrated manner in exposed individuals. The project will also function within the framework of the LabEx CEBA: “Center for the study of biodiversity in Amazonia” and in the CNRS “Observatoire Homme-Milieux” OMH Oyapock station (http://ohmoyapock. in2p3.fr). Our project fulfills the objective of the WP2 of the LabEx aiming at UNDERSTANDING PROTECTIVE IMMUNITY AND IMPROVING VACCINE DEVELOPMENT and particularly the specific aims 1) map new modulatory molecules and biomarkers underlying parasite infections and (ii) use immunomics to guide the search for more efficacious vaccines. |
||
Top 5 publications of the last 5 years |
||
1. Keswani T, Roland J, Herbert F, Delcroix-Genete D, Bauderlique-Le Roy H, Gaayeb L, Cazenave PA, Pied S. (2019) Expression of CD300lf by microglia contributes to resistance to cerebral malaria by impeding the neuroinflammation. Genes Immun. doi: 10.1038/s41435-019-0085-9. 2. Shrivastava SK, Dalko E, Delcroix-Genete D, Herbert F, Cazenave PA, Pied S. (2017) Uptake of parasite-derived vesicles by astrocytes and microglial phagocytosis of infected erythrocytes may drive neuroinflammation in cerebral malaria. Glia. 65(1):75-92. doi: 10.1002/glia.23075. 3. Dalko E, Genete D, Auger F, Dovergne C, Lambert C, Herbert F, Cazenave PA, Roland J, Pied S. (2016) Heme dampens T-cell sequestration by modulating glial cell responses during rodent cerebral malaria. Brain Behav Immun. 58:280-290. doi: 10.1016/j.bbi.2016.07.157. 4. Herbert F, Tchitchek N, Bansal D, Jacques J, Pathak S, Bécavin C, Fesel C, Dalko E, Cazenave PA, Preda C, Ravindran B, Sharma S, Das B, Pied S. (2015) Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17pathway in acute renal failure associated to Plasmodium falciparum malaria. J Transl Med. 13:369. doi: 10.1186/s12967-015-0731-6. 5. Blanc AL, Keswani T, Gorgette O, Bandeira A, Malissen B, Cazenave PA, Pied S. (2015) Suppression of CD4+ Effector Responses by Naturally Occurring CD4+ CD25+ Foxp3+ Regulatory T Cells Contributes to Experimental Cerebral Malaria. Infect Immun. 84(1):329-38. doi: 10.1128/IAI.00717-15. |
The York Biomedical Research Institute (YBRI) are hosting an online live seminar on Friday 24th May 1-2pm BST as part of their biomedical science seminar series. You are all welcome to attend - registration is required via the...
[Communiqué] Congratulations to Arthur Talman, IRD Research Leader in the MIVEGEC laboratory (Montpellier), who has been awarded an Advanced Grant from the European Research Council (ERC) for the project "TROJAN - Molecular mimicry and immune...
Ana Rita Gomes, a CNRS Research Associate at the Laboratory of Pathogens and Host Immunity in Montpellier, and former Postdoctoral fellow of the LabEx ParaFrap, has been awarded the prestigious CNRS Bronze Medal in 2023. This...
. PhD Opportunity, Tours, France Supervision Thesis Supervisor: Sonia LAMANDE; Co-Supervisor: Julie TOTTEY Project: FUNTIONAL CHARACTERISATION OF CYSTEINE CATHEPSINS IN THE APICOMPLEXAN PARASITE CRYPTOSPORIDIUM...
Senior PostDoc position : computational biologist, Paris, France The ParSig team (https://research.pasteur.fr/en/team/molecular-parasitology-and-signaling) at the Institut Pasteur in Paris seeks for a highly...
Researcher in Livestock Immunology for the Study of Animal Trypanosomoses Through a One Health approach, the Intertryp Joint Research Unit (Cirad-IRD) is developing research on interactions between hosts,...
Happy New Year 2024! To kick off this new scientific year, here is the ParaFrap webinar schedule. Since January 2021, ParaFrap has been organizing a series of webinars. This monthly event, held every 2nd Thursday of the month, aims to strengthen...
PostDoc position : functional analysis of P. falciparum early gametocyte proteins, Allschwil, Switzerland The Malaria Gene Regulation Lab of Till Voss is looking for a highly motivated and talented postdoc to...
The team of Dr. Mohamed-Ali Hakimi, in collaboration with Isabelle Coppens (Johns Hopkins University Bloomberg School of Public Health and Malaria Research Institute, Baltimore, MD, USA), has developed a new (epi)genetic method to produce in vitro...
Success for ParaFrap students at MPM2023 Parafrap students won numerous awards at the MPM 2023, Woods Hole USA, 17-21 September 2023. A warm congratulations to all ! Parul Sharma (2nd year PhD under the...
© 2023. All rights reserved MLCOM
Notre site LabEx ParaFrap utilise des cookies pour réaliser des statistiques de visites, partager des contenus sur les réseaux sociaux et améliorer votre expérience. En refusant les cookies, certains services seront amenés à ne pas fonctionner correctement. Nous conservons votre choix pendant 30 jours. Vous pouvez changer d'avis en cliquant sur le bouton 'Cookies' en bas à gauche de chaque page de notre site. En savoir plus
Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.
Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.
Ce site utilise des composants tiers, tels que NotAllowedScript662092237038bReCAPTCHA, Google NotAllowedScript662092236ff34Maps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas
Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.
Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.