French Alliance for Parasitology and Health Care


  Frederic Bringaud




microscope Microbiologie Fondamentale et Pathogénicité (MFP) 
team Energy metabolism of trypanosomes (iMET) 
location Bordeaux
orcid 0000-0003-4552-6877 
email This email address is being protected from spambots. You need JavaScript enabled to view it.
twitter @bringaudf 

Scientific interests and projects

Our group has been working for over 25 years on molecular biology and metabolism of trypanosomes, with a particular interest on the central and energy metabolism of the procyclic (PCF) and bloodstream (BSF) forms of Trypanosoma brucei. One of our main objectives is to elucidate the topology of the metabolic network, including the discovery of new metabolic pathways and the understanding regulations between different metabolic branches. The group is one of the few in the field of parasitology to have developed a combination of state-of-the-art nuclear magnetic resonance (NMR) and mass spectrometry (MS) metabolomic technologies to study metabolism of wild-type parasites, as well as a large collection mutants (single, double and triple mutants) covering most of the known branches of the central metabolism.

Among our recent major acheivements, we have shown that (1) BSF can grow in medium containing glycerol instead of glucose, while glucose was considered the only carbon source used by the parasite in vivo (Pineda et al., 2018). This open new avenues for understanding parasite metabolism in vivo, as it has recently been described that BSF are more abundant in skin and adipose tissues than in blood. Since the adipocytes present in these organs are excellent glycerol-producers, we study the role of glycerol metabolism in the context of extravascular trypanosomes. (2) Gluconeogenesis occurs in PCF and BSF trypanosomes grown in glucose-free conditions, through unexpected redundant pathways under study (Wargnies et al., 2018). (3) As opposed to most organisms, PCF prefer to metabolise glycerol than glucose, and glycerol metabolism represses glucose consumption through a new mechanism name "metabolic contest" (submitted for publication). Interestingly, phospholipases excreted by PCF can produce glycerol from serum-derived phospholipids that could offer a metabolism benefit in vivo, which is under investigation

Top 5 publications of the last 5 years

1. Wargnies M., E. Bertiaux, E. Cahoreau, N. Ziebart, A. Crouzols, P. Morand, M. Biran, S. Allmann, J. Hubert, O. Villafraz, Y. Millerioux, N. Plazolles, C. Asencio, L. Riviere, B. Rotureau, M. Boshart, J.-C. Portais & F. Bringaud (2018) Gluconeogenesis is essential for trypanosome development in the tsetse fly vector. PLoS Pathog. 14:e1007502. 10.1371/journal.ppat.1007502

2. Pineda E., M. Thonnus, M. Mazet, A. Mourier, E. Cahoreau, M. Biran, J.-W. Dupuy, C. Massante, S. Allmann, L. Riviere, B. Rotureau, J.-C. Portais & F. Bringaud (2018) Glycerol supports growth of the Trypanosoma brucei bloodstream forms in the absence of glucose: analysis of metabolic adaptations on glycerol-rich conditions. PLoS Pathog. 14:e1007412. 10.1371/journal.ppat.1007412

3. Millerioux Y., M. Mazet, G. Bouyssou, S. Allmann, T.R. Kiema, C. Thapa, M. Biran, N. Plazolles, L. Fouillen, E. Bertiaux, A. Crouzols, R. Wierenga, B. Rotureau, P. Moreau & F. Bringaud (2018) De novo biosynthesis of lipids in the Trypanosoma brucei procyclic form: carbon source preferences and metabolic flux redistributions and essentiality of the leucine degradation pathway in vivo. PLoS Pathog. 14:e1007116. 10.1371/journal.ppat.1007116

4. Suárez Mantilla B., L. Marchese, N.A. Dyer, N. Ejeh, M. Biran, F. Bringaud, M.J. Lehane, A. Acosta-Serrano & A. Silber (2017) Trypanosoma brucei proline metabolism is essential for colonization of the tsetse. PLoS Pathog. 13:e1006158. 10.1371/journal.ppat.1006158

5. Creek D.J., M. Mazet, F. Achcar, J. Anderson, D.-H. Kim, R. Kamour, P. Morand, Y. Millerioux, M. Biran, E. Kerkhoven, U. Chokkathukalam, K.E.V. Burgess, R. Breitling, D.G. Watson, F. Bringaud & M.P. Barrett (2015) Untargeted stable isotope labelled metabolomics reveals glucose to contribute widely to the metabolic network of bloodstream form Trypanosoma brucei. PLoS Pathog. 11:e1004689. 10.1371/journal.ppat.1004689


International PhD Program


LabEx News
Other News



Project Manager: Yoann MILLERIOUX

Twitter Social Icon Rounded Square Color @ParaFrap #ParaFrap

Cookies settings


Functional Cookies

Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.

Measure of audience

Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.

Interactive Content

Ce site utilise des composants tiers, tels que NotAllowedScript651ba1e16a7cfReCAPTCHA, Google NotAllowedScript651ba1e16a3a2Maps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas

Social Networks / Videos

Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.


Please login to see yours activities!

Other cookies

Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.