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Benoit GAMAIN |
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Information |
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Integrated Biology of the Red Cell | ||||
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Severe Malaria Pathogenesis | ||||
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Paris | ||||
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0000-0002-8255-2145 | ||||
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https://NotAllowedScript6575f93d55032sites.google.com/view/benoitgamainlab/accueil | ||||
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@gamainbenoit | ||||
Scientific interests and projects |
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The Severe Malaria Pathogenesis team was created on July 1st 2010 as an ATIP-Avenir team and renewed twice on January 1st 2014 and January 1st 2019 after HCERES evaluations as an INSERM-Paris Diderot university team. We are focusing our research efforts on the identification and the deciphering of the molecular interactions involved in the Plasmodium falciparum infected erythrocytes cytoadhesion processes to develop vaccine and therapeutic strategies. We have various international collaborations in the malaria, red blood cells and the structural biology fields. During the last years, we have been working mostly on the identification of the host-parasite interactions associated to placental malaria but also severe malaria. Our main discovery results in the structural and functional characterization of the parasite protein (var2CSA) responsible for P. falciparum infected erythrocytes (PEs) sequestration in the placenta. Our results have been the basis to initiate the PRIMALVAC vaccine development program that allowed the down-selection of the PRIMVAC vaccine candidate that has been tested in a Phase Ia/Ib vaccine clinical trial in France and Burkina-Faso. Team members possess unique expertise such as: Our team is working on the interaction between the malaria parasite and the host receptors as well as the impact of abnormal red cells on the parasite. Therefore, we could develop many interactions and develop projects with other ParaFrap members working on these different aspects. |
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Top 5 publications of last 5 years |
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1. Davies H., Belda H., Broncel M., Ye X., Bisson C., Introini V., Dorin-Semblat D., Semblat, J.P., Tibúrcio M., Gamain, B., Kaforou, M., Treeck M., An Exported Kinase Family Mediates Species-Specific Erythrocyte Remodelling and Virulence in Human Malaria. Nature Microbiol, 2019. In Press. 2. Dorin-Semblat D., Tetard M., Claes A., Semblat J.P., Dechavanne S., Fourati Z., Hamelin R., Armand F., Matesic G., Nunes-Silva S., Srivastava A., Gangnard S., Lopez-Rubio J.J., Moniatte M., Doerig C., Scherf A., and Gamain B., Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA. PLoS Biol, 2019. 17(6): p. e3000308. 10.1371/journal.pbio.3000308 3. Chene A., Gangnard S., Guadall A., Ginisty H., Leroy O., Havelange N., Viebig N.K., and Gamain B., Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC. EBioMedicine, 2019. 42: p. 145-156. 10.1016/j.ebiom.2019.03.010 4. Chene A., Gangnard S., Dechavanne C., Dechavanne S., Srivastava A., Tetard M., Hundt S., Leroy O., Havelange N., Viebig N.K., and Gamain B., Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development. NPJ vaccines, 2018. 3: p. 28. 10.1038/s41541-018-0064-6 5. Lennartz F., Adams Y., Bengtsson A., Olsen R.W., Turner L., Ndam N.T., Ecklu-Mensah G., Moussiliou A., Ofori M.F., Gamain B., Lusingu J.P., Petersen J.E., Wang C.W., Nunes- Silva S., Jespersen J.S., Lau C.K., Theander T.G., Lavstsen T., Hviid L., Higgins M.K., and Jensen A.T., Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria. Cell Host Microbe, 2017. 21(3): p. 403-414. 10.1016%2Fj.chom.2017.02.009 |
Success for ParaFrap students at MPM2023 Parafrap students won numerous awards at the MPM 2023, Woods Hole USA, 17-21 September 2023. A warm congratulations to all ! Parul Sharma (2nd year PhD under the...
Predoctoral and Postdoctoral positions - Barcelona, Spain Project Leader: Alfred Cortés, PhD - Barcelona Institute for Global Health Hospital Clínic - Universitat de Barcelona Positions: A predoctoral and two...
PhD Position Perpignan, France Project Leader Ronaldo DE CARVALHO AUGUSTO (CPJ, UPVD), principal supervisor (50%) Jérôme BOISSIER (PU, UPVD), PI (50%) Project: Unveiling the Dark Secrets of Roommate Parasites: A Study...
PostDoc position : Saeij Lab, Davis, California, USA The Saeij lab (https://saeijlab.faculty.ucdavis.edu/) at the University of California, Davis, is currently looking for several postdoctoral scholars to work on...
PostDoc position : Identify new repository molecules against Cryptosporidium, Tours, France The lab seeks to hire a highly motivated candidate to work on the identification of new repository molecules against...
Emerging Leader Research Fellow, Oxford Brookes University, UK The Oxford Brookes University offers an opportunity to develop an independent research group in molecular parasitology/protistology through a...
PostDoc position : Gene regulation/ DNA low complexity regions-DNA binding proteins, Montpellier, France The post-doc project aims to investigate the role of Low Complexity Regions in regulation of gene expression in P....
Short-Term Scientific Missions (STSMs) within the OneHealthdrugs (CA21111) network 1st CALL for applications 2023 The 1st STSM Call of the Action CA2111 OneHealthdrugs is launched. Short Term Scientific Mission...
PostDoc position : Cross-talk between stress response and infection in dendritic cells at Institut Pasteur Lille, France We seek to hire a highly motivated candidate to work on the role of the Unfolded Protein...
[Publication] Les derniers travaux de Rania Najm, Hiba El Hajj, Maryse Lebrun & leurs collègues sont publiés dans PNAS. Les auteurs apportent des connaissances importantes sur les acteurs moléculaires de l'invasion des bradyzoïtes et...
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