Project Title : "Role of the unusual peroxisomal/glycosomal sequestration of cytosolic metabolic pathways in trypanosomes"

Project PI : Frédéric Bringaud  Co-PI : Cyrille Botté 

Thesis defense : 04/12/2020 

Lab : Intermediate and energy metabolism of trypanosomes, UMR5234 CNRS, Bordeaux University

BACKGROUND

• Junior researcher and Teaching Assistant⎪ University of Los Andes, Mérida, Venezuela
• Bachelor's Degree in Biology ⎪ University of Los Andes, Mérida, Venezuela

POSITION AFTER PARAFRAP TRAINING

Postdoctoral researcher at IRCM (Institut de Recherche en Cancérologie de Montpellier), France - Since March 2021

PUBLICATIONS

Villafraz, O., Biran, M., Pineda, E., Plazolles, N., Cahoreau, E., Souza, R.O.O., Thonnus, M., Allmann, S., Tetaud, E., Rivière, L., Silber, A.M., Barrett, M.P., Zíková, A., Boshart, M., Portais, J.-C., Bringaud, F., (2021b). Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline. PLoS Pathog [6.2] 17, e1009204. doi: 10.1371/journal.ppat.1009204

Villafraz, O., Baudouin, H., Mazet, M., Kulyk, H., Dupuy, J.-W., Pineda, E., Botté, C., Inaoka, D., Portais, J.-C., Bringaud, F., (2021a). The trypanosome UDP-glucose pyrophosphorylase is imported by piggybacking into glycosomes where unconventional sugar nucleotide synthesis takes place. bioRxiv [preprint] 2021.02.17.431754. doi: 10.1101/2021.02.17.431754

Michels, P.A.M., Villafraz, O., Pineda, E., Alencar, M.B., Cáceres, A.J., Silber, A.M., Bringaud, F., (2021). Carbohydrate metabolism in trypanosomatids: new insights revealing novel complexity, diversity and species-unique features. Exp Parasitol [1.7] 108102. doi: 10.1016/j.exppara.2021.108102

Wargnies, M., Plazolles, N., Schenk, R., Villafraz, O., Dupuy, J.-W., Biran, M., Bachmaier, S., Baudouin, H., Clayton, C., Boshart, M., Bringaud, F., (2021). Metabolic selection of a homologous recombination mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase *. J Biol Chem [4.2] 0, 100548. doi: 10.1016/j.jbc.2021.100548

Allmann, S., Wargnies, M., Cahoreau, E., Biran, M., Plazolles, N., Morand, P., Pineda, E., Kulyk, H., Asencio, C., Villafraz, O., Rivière, L., Tétaud, E., Rotureau, B., Mourier, A., Portais, J.-C., Bringaud, F., (2019). “Metabolic contest”, a new way to control carbon source preference. bioRxiv [preprint] 800839. doi: 10.1101/800839

Wargnies, M., E. Bertiaux, E. Cahoreau, N. Ziebart, A. Crouzols, P. Morand, M. Biran, S. Allmann, J. Hubert, O. Villafraz, Y. Millerioux, N. Plazolles, C. Asencio, L. Rivière, B. Rotureau, M. Boshart, J.-C. Portais and F. Bringaud (2018). "Gluconeogenesis is essential for trypanosome development in the tsetse fly vector." PLoS Pathog [6.6] 14(12): e1007502. doi: 10.1371/journal.ppat.1007502