Project : "Identification of malaria parasite virulence factors that counteract mosquito natural resistance"

Project PI : Stéphanie Blandin  Co-PI : Olivier Silvie

Lab : Responses in the Anopheles gambiae Malaria Vector, IBMC, University of Strasbourg, France

BACKGROUND

• Phd Fellow in Elisabeth Davioud-Charvet's Lab, Strasbourg, France (2010-2014)

POSITION AFTER PARAFRAP TRAINING

• since 2020: International Business Development, FIZIMED, Strasbourg, France
• 2019: Innovation project manager, University of Strasbourg - France
• 2017-2018: Postdoctoral researcher in Stéphanie Blandin's team, INSERM, Strasbourg - France

PUBLICATIONS

Feng, L., D. A. Lanfranchi, L. Cotos, E. Cesar-Rodo, K. Ehrhardt, A.-A. Goetz, H. Zimmermann, F. Fenaille, S. A. Blandin and E. Davioud-Charvet (2018). "Synthesis of plasmodione metabolites and 13C-enriched plasmodione as chemical tools for drug metabolism investigation." Org Biomol Chem [3.6] 16(15): 2647-2665. [Link]

Urgin, K., M. Jida, K. Ehrhardt, T. Muller, M. Lanzer, L. Maes, M. Elhabiri and E. Davioud-Charvet (2017). "Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties." Molecules [2.5] 22(1). [Link]

Jida, M., C. P. Sanchez, K. Urgin, K. Ehrhardt, S. Mounien, A. Geyer, M. Elhabiri, M. Lanzer and E. Davioud-Charvet (2017). "A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs." ACS Infect Dis [no IF] 3(2): 119-131. [Link]

Rodo, E. C., L. Feng, M. Jida, K. Ehrhardt, M. Bielitza, J. Boilevin, M. Lanzer, D. L. Williams, D. A. Lanfranchi and E. Davioud-Charvet (2016). "A Platform of Regioselective Methodologies to Access Polysubstituted 2-Methyl-1,4-naphthoquinone Derivatives: Scope and Limitations." European Journal of Organic Chemistry [3.1] 2016(11): 1982-1993. [Link]

Ehrhardt, K., C. Deregnaucourt, A. A. Goetz, T. Tzanova, V. Gallo, P. Arese, B. Pradines, S. H. Adjalley, D. Bagrel, S. Blandin, M. Lanzer and E. Davioud-Charvet (2016). "The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites." Antimicrob Agents Chemother [4.5] 60(9): 5146-5158. [Link]

Bielitza, M., D. Belorgey, K. Ehrhardt, L. Johann, D. A. Lanfranchi, V. Gallo, E. Schwarzer, F. Mohring, E. Jortzik, D. L. Williams, K. Becker, P. Arese, M. Elhabiri and E. Davioud-Charvet (2015). "Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats." Antioxid Redox Signal [7.7] 22(15): 1337-1351. [Link]

Ehrhardt, K., E. Davioud-Charvet, H. Ke, A. B. Vaidya, M. Lanzer and M. Deponte (2013). "The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain." Antimicrob Agents Chemother [4.5] 57(5): 2114-2120. [Link]