Artur SCHERF |
||
Information |
||
Biology of Host Parasite Interactions | ||
Paris, Institut Pasteur | ||
0000-0003-2411-3328 | ||
This email address is being protected from spambots. You need JavaScript enabled to view it. | ||
https://research.pasteur.fr/en/team/biology-of-host-parasite-interactions/ | ||
Scientific interests and projects |
||
The ‘Biology of Host-Parasite Interactions (BIHP)’ Unit, led by Prof Artur Scherf (DRCE CNRS), comprises 4 groups with a research focus on malaria parasite virulence, pathogenesis, liver stage infection and host immune responses to establish the molecular and cellular bases of parasite strategies to successfully complete the life cycle. By integrating a novel humanized mouse model, a rodent malaria model and mosquitoes, our studies address key biological aspects of the different stages of the life cycle development of Plasmodium falciparum and P. berghei. Activities of team members within ParaFrap: SCHERF A. has spearheaded the discovery of gene regulatory mechanisms over more than two decades. A main focus is on epigenetic factors that control 3-D spatial organization, transcription and posttranscriptional control of gene regulation with a particular focus on antigenic variation. The team uses routinely a wide array of techniques in literally all stages of the parasite life cycle, including genome-wide approaches such as ChIP-seq and RNA/DNA-seq as well as targeted genome editing. More recently, the team has developed in collaboration with a medicinal chemist (P. Arimondo, Institut Pasteur), distinct epigenetic compounds that kill efficiently multidrug resistant P. falciparum including artemisinin resistant strains and are active against transmission stages. Validation of lead epigenetic compounds using P. falciparum and P. vivax liver stages including hypnozoites, infected mosquitoes and humanized mouse models is an ongoing activity. MANCIO SILVA L. has a long-term interest in understanding the malaria parasite interaction with hepatocytes and the interventions needed to control malaria disease. She is using rodent malaria models, sophisticated human hepatocyte culture systems and live imaging approaches to study sporozoite invasion and development in hepatocytes with a focus on the role of distinct metabolic states of host cells in infection. GARCIA S. has a strong expertise on humanized mouse experimentation and has improved this model for studies of P. falciparum with the potential to establish this new model to study P. vivax. |
||
Top 5 publications of the last 5 years |
||
1. Baumgarten S, Bryant JM, Sinha A, Reyser T, Preiser PR, Dedon PC, Scherf A. Transcriptome-wide dynamics of extensive m6A mRNA methylation during Plasmodium falciparum blood-stage development. Nat Microbiol. 2019 Aug 5. doi: 10.1038/s41564-019-0521-7. 2. Mancio-Silva L, Slavic K, Grilo Ruivo MT, Grosso AR, Modrzynska KK, Vera IM, Sales-Dias J, Gomes AR, MacPherson CR, Crozet P, Adamo M, Baena-Gonzalez E, Tewari R, Llinás M, Billker O, Mota MM. Nutrient sensing modulates malaria parasite virulence. Nature. 2017 Jul 13;547(7662):213-216. doi: 10.1038/nature23009. 3. MacPherson C. and A. Scherf. Protospacer Workbench: flexible guide-RNA design for CRISPR applications. Nat. Biotechnol. 2015 Aug;33(8):805-6. doi: 10.1038/nbt.3291. Epub 2015 Jun 29.3 4. Ghorbal M, Gorman M, Macpherson CR, Martins RM, Scherf A, Lopez-Rubio JJ. Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system. Nat Biotechnol. 2014 Jun 1. doi: 10.1038/nbt.2925 5. Zhang Q, Siegel TN, Martins RM, Wang F, Cao J, Gao Q, Cheng X, Jiang L, Hon CC, Scheidig-Benatar C, Sakamoto H, Turner L, Jensen AT, Claes A, Guizetti J, Malmquist NA, Scherf A. Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria. Nature. 2014 Jun 29. (Research Highlights in Nat. Reviews Microbiol) doi: 10.1038/nature13468 |
Ana Rita Gomes, a CNRS Research Associate at the Laboratory of Pathogens and Host Immunity in Montpellier, and former Postdoctoral fellow of the LabEx ParaFrap, has been awarded the prestigious CNRS Bronze Medal in 2023. This...
. PhD Opportunity, Tours, France Supervision Thesis Supervisor: Sonia LAMANDE; Co-Supervisor: Julie TOTTEY Project: FUNTIONAL CHARACTERISATION OF CYSTEINE CATHEPSINS IN THE APICOMPLEXAN PARASITE CRYPTOSPORIDIUM...
Senior PostDoc position : computational biologist, Paris, France The ParSig team (https://research.pasteur.fr/en/team/molecular-parasitology-and-signaling) at the Institut Pasteur in Paris seeks for a highly...
Researcher in Livestock Immunology for the Study of Animal Trypanosomoses Through a One Health approach, the Intertryp Joint Research Unit (Cirad-IRD) is developing research on interactions between hosts,...
Happy New Year 2024! To kick off this new scientific year, here is the ParaFrap webinar schedule. Since January 2021, ParaFrap has been organizing a series of webinars. This monthly event, held every 2nd Thursday of the month, aims to strengthen...
PostDoc position : functional analysis of P. falciparum early gametocyte proteins, Allschwil, Switzerland The Malaria Gene Regulation Lab of Till Voss is looking for a highly motivated and talented postdoc to...
The team of Dr. Mohamed-Ali Hakimi, in collaboration with Isabelle Coppens (Johns Hopkins University Bloomberg School of Public Health and Malaria Research Institute, Baltimore, MD, USA), has developed a new (epi)genetic method to produce in vitro...
Success for ParaFrap students at MPM2023 Parafrap students won numerous awards at the MPM 2023, Woods Hole USA, 17-21 September 2023. A warm congratulations to all ! Parul Sharma (2nd year PhD under the...
Predoctoral and Postdoctoral positions - Barcelona, Spain Project Leader: Alfred Cortés, PhD - Barcelona Institute for Global Health Hospital Clínic - Universitat de Barcelona Positions: A predoctoral and two...
PhD Position Perpignan, France Project Leader Ronaldo DE CARVALHO AUGUSTO (CPJ, UPVD), principal supervisor (50%) Jérôme BOISSIER (PU, UPVD), PI (50%) Project: Unveiling the Dark Secrets of Roommate Parasites: A Study...
© 2023. All rights reserved MLCOM
Notre site LabEx ParaFrap utilise des cookies pour réaliser des statistiques de visites, partager des contenus sur les réseaux sociaux et améliorer votre expérience. En refusant les cookies, certains services seront amenés à ne pas fonctionner correctement. Nous conservons votre choix pendant 30 jours. Vous pouvez changer d'avis en cliquant sur le bouton 'Cookies' en bas à gauche de chaque page de notre site. En savoir plus
Ce site utilise des cookies pour assurer son bon fonctionnement et ne peuvent pas être désactivés de nos systèmes. Nous ne les utilisons pas à des fins publicitaires. Si ces cookies sont bloqués, certaines parties du site ne pourront pas fonctionner.
Ce site utilise des cookies de mesure et d’analyse d’audience, tels que Google Analytics et Google Ads, afin d’évaluer et d’améliorer notre site internet.
Ce site utilise des composants tiers, tels que NotAllowedScript66052bd75d5ddReCAPTCHA, Google NotAllowedScript66052bd75d1a7Maps, MailChimp ou Calameo, qui peuvent déposer des cookies sur votre machine. Si vous décider de bloquer un composant, le contenu ne s’affichera pas
Des plug-ins de réseaux sociaux et de vidéos, qui exploitent des cookies, sont présents sur ce site web. Ils permettent d’améliorer la convivialité et la promotion du site grâce à différentes interactions sociales.
Ce site web utilise un certain nombre de cookies pour gérer, par exemple, les sessions utilisateurs.